Wang Chengfeng, Zhao Ping, Wang Jing, Song Deyu
Department of Surgery, Tumor Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, China.
Zhonghua Wai Ke Za Zhi. 2002 Dec;40(12):902-4.
To investigate the epidemiological and clinical features of multiple primary malignant neoplasms (MPMNs).
One hundred and twenty-five cases of more than or equal to three primary malignant neoplasms detected in the period of 1958 to 2001 were studied retrospectively in terms of frequency, age of onset, sex ratio, tumor location and the interval between sequential tumors.
The overall incidence of MPMNs was 0.090%; for three, four and five MPMNs was 0.078%, 0.009% and 0.001%. The mean age of onset of MPMNs was 64 years. The sex ratio, of male to female, was 1.0:1.2. The mean time interval was 7.1 years, and it reduced from 5.7 to 2.4 years in a descending order of the first, second, third, forth and fifth primary tumors. Three, four and five primary malignant neoplasms were predicated respectively in the large intestine, breast, lung, esophagus, uterus, skin; the large intestine, breast, skin stomach, urinary bladder, uterus; and the large intestine, breast, skin, parotid glands.
The overall incidence of multiple primary malignant neoplasms seems to ascend. The age of onset of MPMNs tends to be increase. The incidence of in women is higher than in men. The time interval from the first to fifth primary tumor is decreasing. The susceptible organs are identical organ, bigeminal organs or organs of the same system.
探讨多原发性恶性肿瘤（MPMNs）的流行病学及临床特征。
回顾性研究1958年至2001年期间检测出的125例患有三个及以上原发性恶性肿瘤的病例，分析其发病频率、发病年龄、性别比、肿瘤部位以及相继发生肿瘤之间的间隔时间。
MPMNs的总体发病率为0.090%；三个原发性恶性肿瘤的发病率为0.078%，四个为0.009%，五个为0.001%。MPMNs的平均发病年龄为64岁。男女比例为1.0:1.2。平均时间间隔为7.1年，从第一个、第二个、第三个、第四个到第五个原发性肿瘤，时间间隔依次从5.7年降至2.4年。三个、四个和五个原发性恶性肿瘤分别好发于大肠、乳腺、肺、食管、子宫、皮肤；大肠、乳腺、皮肤、胃、膀胱、子宫；以及大肠、乳腺、皮肤、腮腺。
多原发性恶性肿瘤的总体发病率似乎呈上升趋势。MPMNs的发病年龄趋于增大。女性发病率高于男性。从第一个到第五个原发性肿瘤的时间间隔在缩短。易感器官为同一器官、成对器官或同一系统的器官。
