Fukagai T, Ishihara M, Funabashi K, Naitoh Y, Maruyama K
Department of Urology, Tokyo Metropolitan Hiroo General Hospital, Japan.
Hinyokika Kiyo. 1996 Mar;42(3):181-5.
Between October 1980 and December 1994, we treated 392 patients with malignant neoplasms associated with genitourinary organs. We made a statistical study on 42 patients (10.6%) with multiple malignant neoplasms. The average age of 42 patients was 72.2 years and 83% of the patients were male. Malignant neoplasms originating from bladder, prostate or kidney were observed in 19 cases (35%), 19 cases (35%) or 10 cases (11%), respectively. The incidence of prostatic cancer was higher than that in other single primary malignant neoplasms associated with genitourinary organs. The other organs having malignant neoplasms accompanying genitourinary organs were the stomach (39%), lungs (12%), esophagus (9%), and pancreas (9%). Only 16 patients (35%) had synchronous multiple malignant neoplasms. However, 35 cases (75%) including these cases had second primary malignant neoplasms within 5 years of the first. In conclusion, the incidence of multiple malignant neoplasms with genitourinary cancer was as high as 10.6% and the prognosis of these patients was poor. These findings suggest the necessity of careful follow-up on patients with genitourinary cancer.
1980年10月至1994年12月期间，我们治疗了392例泌尿生殖器官相关恶性肿瘤患者。我们对42例（10.6%）患有多发性恶性肿瘤的患者进行了统计研究。42例患者的平均年龄为72.2岁，其中83%为男性。分别观察到19例（35%）、19例（35%）和10例（11%）起源于膀胱、前列腺或肾脏的恶性肿瘤。前列腺癌的发病率高于其他与泌尿生殖器官相关的单一原发性恶性肿瘤。伴随泌尿生殖器官出现恶性肿瘤的其他器官为胃（39%）、肺（12%）、食管（9%）和胰腺（9%）。只有16例患者（35%）患有同步多发性恶性肿瘤。然而，包括这些病例在内，有35例（75%）在首次发病后的5年内出现了第二原发性恶性肿瘤。总之，泌尿生殖系统癌症并发多发性恶性肿瘤的发病率高达10.6%，这些患者的预后较差。这些发现表明对泌尿生殖系统癌症患者进行仔细随访的必要性。
