小鼠钙调蛋白依赖性蛋白激酶激酶β（CaMKKβ）的克隆及成年小鼠脑中CaMKKβ和CaMKKα分布的特征分析。
Cloning of mouse Ca2+/calmodulin-dependent protein kinase kinase beta (CaMKKbeta) and characterization of CaMKKbeta and CaMKKalpha distribution in the adult mouse brain.
作者信息
Vinet Jonathan, Carra Serena, Blom Joan M C, Harvey Mario, Brunello Nicoletta, Barden Nicholas, Tascedda Fabio
机构信息
Dipartimento di Scienze Farmaceutiche, Università degli Studi di Modena e Reggio Emilia, Via Campi 183, 41100 Modena, Italy.
出版信息
Brain Res Mol Brain Res. 2003 Mar 17;111(1-2):216-21. doi: 10.1016/s0169-328x(02)00698-8.
The Ca(2+)/calmodulin-dependent protein kinase kinases alpha and beta (CaMKKs alpha and beta) are novel members of the CaM kinase family. The CaMKKbeta was cloned from mouse brain. The deduced amino acid sequence shared 96.43% homology with the rat CaMKKbeta. Both the alpha and beta isoforms were widely distributed throughout the adult mouse brain. Additionally, all peripheral tissues examined displayed CaMKK alpha and beta expression.
钙（2+）/钙调蛋白依赖性蛋白激酶激酶α和β（CaMKKsα和β）是CaM激酶家族的新成员。CaMKKβ是从小鼠脑中克隆出来的。推导的氨基酸序列与大鼠CaMKKβ有96.43%的同源性。α和β亚型在成年小鼠脑中广泛分布。此外，所有检测的外周组织均显示有CaMKKα和β的表达。
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