钙/钙调蛋白依赖性蛋白激酶激酶 2：在信号转导和病理生理学中的作用。
Calcium/calmodulin-dependent protein kinase kinase 2: roles in signaling and pathophysiology.
机构信息
Department of Pharmacology and Cancer Biology, Duke University Medical Center, Duke University, Durham, North Carolina 27710, USA.
出版信息
J Biol Chem. 2012 Sep 14;287(38):31658-65. doi: 10.1074/jbc.R112.356485. Epub 2012 Jul 9.
Abstract
Many cellular Ca(2+)-dependent signaling cascades utilize calmodulin (CaM) as the intracellular Ca(2+) receptor. Ca(2+)/CaM binds and activates a plethora of enzymes, including CaM kinases (CaMKs). CaMKK2 is one of the most versatile of the CaMKs and will phosphorylate and activate CaMKI, CaMKIV, and AMP-activated protein kinase. Cell expression of CaMKK2 is limited, yet CaMKK2 is involved in regulating many important physiological and pathophysiological processes, including energy balance, adiposity, glucose homeostasis, hematopoiesis, inflammation, and cancer. Here, we explore known functions of CaMKK2 and discuss its potential as a target for therapeutic intervention.
摘要
许多细胞内钙离子依赖的信号级联反应利用钙调蛋白（CaM）作为细胞内钙离子的受体。钙离子/钙调蛋白结合并激活大量的酶，包括钙调蛋白激酶（CaMKs）。CaMKK2 是 CaMKs 中最具多功能性的一种，可磷酸化并激活 CaMKI、CaMKIV 和 AMP 激活的蛋白激酶。CaMKK2 的细胞表达受到限制，但 CaMKK2 参与调节许多重要的生理和病理生理过程，包括能量平衡、肥胖、葡萄糖稳态、造血、炎症和癌症。在这里，我们探讨了 CaMKK2 的已知功能，并讨论了其作为治疗干预靶点的潜力。
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