Würsten D
Schweiz Med Wochenschr. 1976 Mar 27;106(13):455-9.
Since secondary deep mycoses are frequently seen in internal medicine nowadays, increasing interest has been focused on antimycotic therapy. This report deals with the limited available range of antimycotic substances which can be administered systemically. Since severe adverse effects are often observed with Amphotericin-B, the most effective antifungal agent, the advent of three new systemic antifungal drugs (Clotrimazole, Miconazole, 5-Fluorocytosine) has proven to be a real advance in our therapeutic approach to deep mycoses. To avoid unwanted side-effects, combined therapy with low doses of Amphotericin-B and another antimycotic agent promises to become increasingly important.
由于继发性深部真菌病如今在内科中屡见不鲜，抗真菌治疗已受到越来越多的关注。本报告探讨了可全身给药的抗真菌物质种类有限的情况。由于两性霉素B（最有效的抗真菌剂）常伴有严重的不良反应，三种新型全身用抗真菌药物（克霉唑、咪康唑、5-氟胞嘧啶）的出现，已被证明是我们治疗深部真菌病方法上的一大进步。为避免出现不良副作用，低剂量两性霉素B与另一种抗真菌剂联合治疗有望变得越来越重要。
