肿瘤坏死因子α在痢疾志贺菌相关惊厥中的双向浓度依赖性作用。
Bidirectional concentration-dependent effects of tumor necrosis factor alpha in Shigella dysenteriae-related seizures.
作者信息
Yuhas Yael, Weizman Abraham, Ashkenazi Shai
机构信息
Felsenstein Medical Research Cente, Beilinson Campus, Tel Aviv University, Tel Aviv, Israel.
出版信息
Infect Immun. 2003 Apr;71(4):2288-91. doi: 10.1128/IAI.71.4.2288-2291.2003.
Abstract
We have previously demonstrated that pretreatment of mice with Shigella dysenteriae sonicate enhanced their susceptibility to pentylenetetrazole-induced seizures and that tumor necrosis factor alpha (TNF-alpha) was proconvulsive in this respect. The present study shows that TNF-alpha, at high concentrations, may also exert a suppressive effect on Shigella-mediated seizures. This implies that high levels of TNF-alpha may play a protective role in neurologic complications of S. dysenteriae infection.
摘要
我们之前已经证明，用痢疾志贺氏菌超声裂解物预处理小鼠会增强它们对戊四氮诱导惊厥的易感性，并且在这方面肿瘤坏死因子α（TNF-α）具有促惊厥作用。本研究表明，高浓度的TNF-α也可能对志贺氏菌介导的惊厥产生抑制作用。这意味着高水平的TNF-α可能在痢疾志贺氏菌感染的神经系统并发症中起保护作用。
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