患有复杂性志贺菌病儿童粪便中的细胞因子
Cytokines in the stools of children with complicated shigellosis.
作者信息
Azim T, Halder R C, Sarker M S, Ahmed S, Hamadani J, Chowdhury A, Qadri F, Salam M A, Sack R B, Albert M J
机构信息
International Centre for Diarrhoeal Disease Research, Bangladesh, Dhaka.
出版信息
Clin Diagn Lab Immunol. 1995 Jul;2(4):492-5. doi: 10.1128/cdli.2.4.492-495.1995.
The pathogenesis of the systemic complications, leukemoid reaction and hemolytic uremic syndrome, associated with Shigella dysenteriae type 1 infection is not well understood. The excessive production of proinflammatory cytokines, including tumor necrosis factor alpha (TNF-alpha) and interleukin 6 (IL-6), has been suggested as a possible factor. We measured IL-6 and TNF-alpha in stools of 56 children with S. dysenteriae 1 infection and 29 children without any apparent infection, all age 12 to 60 months. Sixteen children with S. dysenteriae 1 infection had leukemoid reaction or hemolytic uremic syndrome (complicated shigellosis), while the others did not (uncomplicated shigellosis). Stool IL-6 and TNF-alpha concentrations were higher in children with uncomplicated shigellosis than in children with complicated shigellosis (P = 0.009 and < 0.001, respectively) or in uninfected children (P < 0.001). It is concluded that complicated infection is not associated with higher concentrations of the proinflammatory cytokines IL-6 and TNF-alpha in stool.
与1型痢疾志贺菌感染相关的全身并发症、类白血病反应和溶血尿毒综合征的发病机制尚未完全明确。促炎细胞因子的过度产生，包括肿瘤坏死因子α（TNF-α）和白细胞介素6（IL-6），被认为是一个可能的因素。我们检测了56例12至60个月龄感染1型痢疾志贺菌的儿童以及29例无明显感染的儿童粪便中的IL-6和TNF-α。16例感染1型痢疾志贺菌的儿童出现了类白血病反应或溶血尿毒综合征（复杂性志贺菌病），而其他儿童未出现（非复杂性志贺菌病）。非复杂性志贺菌病患儿粪便中的IL-6和TNF-α浓度高于复杂性志贺菌病患儿（P分别为0.009和<0.001）或未感染儿童（P<0.001）。研究得出结论，复杂性感染与粪便中促炎细胞因子IL-6和TNF-α的较高浓度无关。
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