Suprun H, Rywlin A M
South Med J. 1976 Apr;69(4):438-9. doi: 10.1097/00007611-197604000-00018.
The incidence of metastatic carcinoma in bone marrow was studied by two different approaches in 220 consecutive autopsies of patients with carcinoma: histologic sections of aspirates from the iliac spine, as usually done in living patients; and gross and microscopic examination of the thoracolumbar spine. Ten percent of the autopsies showed bone marrow metastases by the aspiration technic as contrasted with 34.5% by the autopsy technic. Three cases had positive bone marrow aspirates in the absence of metastases demonstrable by routine autopsy. The combination of autopsy and aspiration technics yielded an incidence of metastatic marrow involvement of 35.9%. Of patients with marrow metastases at autopsy, 25% also had positive aspirates. This study establishes a norm for the comparison of the efficiency of discovery of metastatic carcinoma by different modalities of clinical bone marrow sampling.
通过两种不同方法，对220例连续尸检的癌症患者骨髓中转移性癌的发生率进行了研究：像在活体患者中通常所做的那样，对髂嵴穿刺物进行组织学切片检查；以及对胸腰椎进行大体和显微镜检查。10%的尸检通过穿刺技术显示有骨髓转移，相比之下，尸检技术显示的比例为34.5%。有3例骨髓穿刺呈阳性，但常规尸检未发现转移。尸检和穿刺技术相结合得出骨髓转移受累的发生率为35.9%。尸检时有骨髓转移的患者中，25%的患者穿刺结果也呈阳性。本研究确立了一个标准，用于比较通过不同临床骨髓采样方式发现转移性癌的效率。
