Reynolds N R
Ohio State University, CON, 1585 Neil Avenue, Columbus, OH 43210, USA.
AIDS Care. 2003 Feb;15(1):117-24. doi: 10.1080/0954012021000039815.
Controlled trials that determine which interventions can significantly improve adherence to combination antiretroviral regimens are urgently needed. Rates of adherence to the regimens are often sub-optimal, and while a variety of factors that are predictive or associated with antiretroviral adherence have been identified, few research findings are reported of interventions that effectively promote adherence and improve health outcomes. Further, the mechanisms by which interventions promote antiretroviral adherence are not well understood. Maximizing adherence and achieving the full potential of the antiretroviral therapies demand multidimensional initiatives that address complex behavioural and biomedical issues. A model drawn from self-regulation theory and empirical data to explain antiretroviral medication adherence is proposed.
迫切需要进行对照试验，以确定哪些干预措施能够显著提高对抗逆转录病毒联合疗法的依从性。这些疗法的依从率往往不理想，虽然已经确定了多种预测或与抗逆转录病毒治疗依从性相关的因素，但很少有关于有效促进依从性并改善健康结果的干预措施的研究结果报告。此外，干预措施促进抗逆转录病毒治疗依从性的机制尚未得到很好的理解。最大限度地提高依从性并充分发挥抗逆转录病毒疗法的潜力需要采取多维度举措，以解决复杂的行为和生物医学问题。本文提出了一个基于自我调节理论和实证数据的模型，用于解释抗逆转录病毒药物治疗的依从性。
