Masek K, Kadlecová O, Petrovický P
Z Immunitatsforsch Exp Klin Immunol. 1975 Jul;149(2-4):273-82.
The lipopolysaccharides from P. aeruginosa, S. minnesota and mucopeptide from Streptococcus group A injected intravenously into rats induce a dose-dependent changes of temperature. Simultaneously, a profound disturbance of sleep occurs. The administration of salicylate, which markedly suppressed the fever does not influence the mucopeptide-caused sleep disturbance. The most prominent change in the sleep pattern is a marked decrease of the total time of paradoxical sleep. The measurement of turnover rates of 5-hydroxytryptamine (5-HT) and noradrenaline (NA) in hypothalamus and midbrain, areas involved in temperature and sleep control, after injection of streptococcal mucopeptide demonstrated a significant increase of 5-HT turnover in both areas during fever and paradoxical sleep deprivation. Small electrolytic lesions of the dorsal raphe nuclei which are the largest collection of neural cells containing 5-HT completely eliminated the pyrogenic potency of mucopeptide. The findings suggest that some bacterial products might increase the body temperature through the interference with activity of 5-HT-containing neurons of the raphe complex.
将铜绿假单胞菌、明尼苏达沙门氏菌的脂多糖以及A组链球菌的粘肽静脉注射到大鼠体内，会引起体温的剂量依赖性变化。同时，睡眠会出现严重紊乱。使用能显著抑制发热的水杨酸盐，并不会影响粘肽引起的睡眠紊乱。睡眠模式最显著的变化是异相睡眠总时长显著减少。在注射链球菌粘肽后，对下丘脑和中脑（参与体温和睡眠控制的区域）中5-羟色胺（5-HT）和去甲肾上腺素（NA）的转换率进行测量，结果显示在发热和异相睡眠剥夺期间，这两个区域的5-HT转换率均显著增加。作为含5-HT的神经细胞最大集合的中缝背核的小电解损伤，完全消除了粘肽的致热效力。这些发现表明，某些细菌产物可能通过干扰中缝复合体中含5-HT神经元的活性来升高体温。
