溶血性链球菌细胞壁粘肽的生物学特性
Biological properties of cell wall mucopeptide of hemolytic streptococci.
作者信息
Rotta J, Bednár B
出版信息
J Exp Med. 1969 Jul 1;130(1):31-47. doi: 10.1084/jem.130.1.31.
Abstract
Several of the toxic properties of streptococcal mucopeptide have been studied in detail. Intravenous injection of as little as 1 microg of mucopeptide, solubilized by ultrasonic treatment, elicits a reproducible febrile response. Rabbits which are made tolerant to Escherichia coli endotoxin are only partially tolerant to the subsequent injection of streptococcal mucopeptide. Soluble mucopeptide was successfully employed to prepare and provoke the localized Shwartzman reaction. Intravenous injection of 80 microg of solubilized mucopeptide leads to diffuse cellular infiltration as well as focal areas of myocardial necrosis, surrounded by inflammatory cells.
摘要
链球菌粘肽的几种毒性特性已得到详细研究。静脉注射低至1微克经超声处理溶解的粘肽，会引发可重复的发热反应。对大肠杆菌内毒素产生耐受性的兔子，对随后注射的链球菌粘肽仅部分耐受。可溶性粘肽成功用于制备和引发局部施瓦茨曼反应。静脉注射80微克溶解的粘肽会导致弥漫性细胞浸润以及心肌坏死灶，周围有炎性细胞。
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