Goodman T L, Todd M E, Goldsmith E I
Surg Gynecol Obstet. 1976 May;142(5):673-85.
Laboratory and clinical experience in the monitoring of circulating heparin concentration of bioassay shows that the whole blood clotting time and the activated partial thromboplastin time differ in their reflection of the state of anticoagulation. The decay of biologic activity may be as short as 30 minutes in one patient or as long as 360 minutes in another. This fact may drastically affect patient response to the drug. Safe and rational clinical heparinization is dependent upon periodic monitoring of the circulating heparin concentration. The success of this method was illustrated in two representative patients.
实验室监测循环肝素浓度的生物测定及临床经验表明，全血凝固时间和活化部分凝血活酶时间在反映抗凝状态方面存在差异。生物活性的衰减在一名患者中可能短至30分钟，而在另一名患者中可能长达360分钟。这一事实可能会极大地影响患者对药物的反应。安全合理的临床肝素化依赖于对循环肝素浓度的定期监测。两名代表性患者说明了该方法的成功。
