Overholser K A, Baysinger C B, Harris T R, Deveau T
Thromb Haemost. 1976 Apr 30;35(2):447-59.
The influence of sodium heparin on viscoelastic change during coagulation was determined in vitro for whole blood samples from ten normal subjects at heparin concentrations ranging from 0 to 1.45 units/(ml whole blood). A four-parameter chemorheological model was used to describe the time course of coagulation as measured by the Weissenberg Rheogoniometer. One parameter compares closely with the whole blood activated partial thromboplastin time, while the other three may be related to the chemical kinetics of clotting. The chemorheological model and experimental techniques were then tested in a dog preparation. It was found that rheological measurements are more self-consistent than either thrombelastography or the activated partial thromboplastin time for the assay of in vivo heparin in two dogs.
在体外测定了肝素钠对来自10名正常受试者的全血样本在凝血过程中粘弹性变化的影响，肝素浓度范围为0至1.45单位/（毫升全血）。使用一个四参数化学流变学模型来描述用魏森贝格流变仪测量的凝血时间进程。一个参数与全血活化部分凝血活酶时间密切相关，而其他三个参数可能与凝血的化学动力学有关。然后在犬实验制剂中对化学流变学模型和实验技术进行了测试。发现在两只犬体内，流变学测量对于体内肝素测定比血栓弹力图或活化部分凝血活酶时间更具自洽性。
