Wahlin Anders, Golovleva Irina
The Department of Epidemiology, Umeå University, Umeå, Sweden.
Eur J Haematol. 2003 Apr;70(4):240-1. doi: 10.1034/j.1600-0609.2003.00043.x.
A 58-yr-old male patient with essential thrombocythaemia (ET) developed chronic myeloid leukaemia (CML) after continuous uneventful treatment with hydroxyurea for 18 yr. G-banding analyses of bone marrow cells had repeatedly demonstrated normal male karyotype before this event, but t(9;22)(q34;q11) was demonstrated after the event. An unrelated allogeneic stem cell transplantation was performed. Blood and bone marrow morphology, and the karyotype were normalised and the patient is in good health 1 yr post-transplant. There are no previous reports in the literature about the emergence of CML during treatment with hydroxyurea.
一名58岁的原发性血小板增多症（ET）男性患者，在接受羟基脲持续治疗18年且病情平稳后，发展为慢性髓性白血病（CML）。在这一情况发生之前，对骨髓细胞进行的G显带分析多次显示为正常男性核型，但之后显示出t(9;22)(q34;q11)。进行了无关供体的异基因干细胞移植。血液和骨髓形态以及核型恢复正常，患者在移植后1年健康状况良好。文献中此前没有关于在羟基脲治疗期间出现CML的报道。
