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苯并[f]萘啶酮类：一类对多重耐药革兰氏阳性病原体具有活性的新型局部用抗菌剂。

Benzo[f]naphtyridones: a new family of topical antibacterial agents active on multi-resistant Gram-positive pathogens.

作者信息

Tabart Michel, Picaut Guy, Lavergne Marc, Wentzler Sylvie, Malleron Jean-Luc, Dutka-Malen Sylvie, Berthaud Nadine

机构信息

Aventis Pharma, Centre de Recherche de Vitry Alfortville, 13 Quai Jules Guesde, 94403, Vitry sur Seine, France.

出版信息

Bioorg Med Chem Lett. 2003 Apr 7;13(7):1329-31. doi: 10.1016/s0960-894x(03)00057-x.

DOI:10.1016/s0960-894x(03)00057-x
PMID:12657275
Abstract

The synthesis and antibacterial activity of benzo[f][1,7]naphtyridone derivatives are reported. These compounds are potent antibacterial agents with a Gram-positive spectrum of activity. They are active against multi-resistant cocci, especially Staphylococcus aureus strains. Their physico-chemical and biological properties make them particularly suitable for topical antibacterial use.

摘要

报道了苯并[f][1,7]萘啶酮衍生物的合成及其抗菌活性。这些化合物是具有革兰氏阳性活性谱的强效抗菌剂。它们对多重耐药球菌具有活性，尤其是金黄色葡萄球菌菌株。它们的物理化学和生物学特性使其特别适合用于局部抗菌。

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