Department of Dermatology and Venereology, Sahlgrenska University Hospital, SE-413 45 Göteborg, Sweden.
Acta Derm Venereol. 2010 May;90(3):239-45. doi: 10.2340/00015555-0840.
The aim of this study was to investigate the antimicrobial activity of currently available topical skin pharmaceuticals against Candida albicans, Escherichia coli, Staphylococcus aureus, Staphylococcus epidermidis and Streptococcus pyogenes. The agar dilution assay was used to determine the minimal inhibitory concentration for cream formulations and their active substances. Corticosteroid formulations with the antiseptics clioquinol or halquinol were active against all microbes. The hydrogen peroxide formulation was primarily active against staphylococci. Clotrimazole, miconazole and econazole showed an effect against staphylococci in addition to their effect on C. albicans. In contrast, terbinafine had no antibacterial effect. Fusidic acid was active against staphylococci, with slightly weaker activity against S. pyogenes and no activity against C. albicans or E. coli. In summary, some topical skin pharmaceuticals have broad antimicrobial activity in vitro, clioquinol and halquinol being the most diverse. In limited superficial skin infection topical treatment can be an alternative to systemic antibiotics and should be considered. With the global threat of multi-resistant bacteria there is a need for new, topical, non-resistance-promoting, antimicrobial preparations for the treatment of skin infections.
本研究旨在调查目前市售的局部皮肤药物对白色念珠菌、大肠杆菌、金黄色葡萄球菌、表皮葡萄球菌和化脓性链球菌的抗菌活性。琼脂稀释法测定乳膏制剂及其活性物质的最小抑菌浓度。含防腐剂氯己定或卤卡西林的皮质类固醇制剂对所有微生物均有活性。含过氧化氢的制剂主要对葡萄球菌有活性。克霉唑、咪康唑和益康唑除对白色念珠菌有效外，对葡萄球菌也有作用。相比之下，特比萘芬没有抗菌作用。夫西地酸对葡萄球菌有活性，对化脓性链球菌的活性稍弱，对白色念珠菌和大肠杆菌无活性。综上所述，一些局部皮肤药物在体外具有广泛的抗菌活性，其中氯己定和卤卡西林的抗菌谱最广。在有限的浅表皮肤感染中，局部治疗可以替代全身抗生素，应予以考虑。由于全球存在多耐药菌的威胁，因此需要新的、局部的、非耐药促进的、用于治疗皮肤感染的抗菌制剂。
