Isbister Geoffrey K, Seymour Jamie E, Gray Michael R, Raven Robert J
Discipline of Clinical Pharmacology, University of Newcastle, Waratah, NSW 2298, Australia.
Toxicon. 2003 Mar;41(4):519-24. doi: 10.1016/s0041-0101(02)00395-1.
Spiders of the family Theraphosidae occur throughout most tropical regions of the world. There have only been three case reports of bites by these spiders in Australia. The aim of this study was to describe the clinical effects of bites by Australian theraphosid spiders in both humans and canines. Cases of spider bite were collected by the authors over the period January 1978-April 2002, either prospectively in a large study of Australian spider bites, or retrospectively from cases reported to the authors. Subjects were included if they had a definite bite and had collected the spider. The spiders were identified by an expert arachnologist to genus and species level where possible. There were nine confirmed bites by spiders of the family Theraphosidae in humans and seven in canines. These included bites by two Selenocosmia spp. and by two Phlogiellus spp. The nine spider bites in humans did not cause major effects. Local pain was the commonest effect, with severe pain in four of seven cases where severity of pain was recorded. Puncture marks or bleeding were the next most common effect. In one case the spider had bitten through the patient's fingernail. Mild systemic effects occurred in one of nine cases. There were seven bites in dogs (Phlogellius spp. and Selenocosmia spp.), and in two of these the owner was bitten after the dog. In all seven cases the dog died, and as rapidly as 0.5-2h after the bite. This small series of bites by Australian theraphosid spiders gives an indication of the spectrum of toxicity of these spiders in humans. Bites by these spiders are unlikely to cause major problems in humans. The study also demonstrates that the venom is far more toxic to canines.
捕鸟蛛科蜘蛛分布于世界大部分热带地区。在澳大利亚,仅有三例被这些蜘蛛咬伤的病例报告。本研究的目的是描述澳大利亚捕鸟蛛科蜘蛛对人类和犬类咬伤的临床影响。作者在1978年1月至2002年4月期间收集蜘蛛咬伤病例,这些病例要么是在一项关于澳大利亚蜘蛛咬伤的大型前瞻性研究中收集的,要么是从报告给作者的病例中回顾性收集的。如果受试者有明确的咬伤且捕获了蜘蛛,则将其纳入研究。蜘蛛由专业的蛛形学家尽可能鉴定到属和种的水平。有9例人类被捕鸟蛛科蜘蛛咬伤得到确诊,7例犬类被咬伤。其中包括被两种澳毒蛛属蜘蛛和两种粗螯蛛属蜘蛛咬伤。9例人类蜘蛛咬伤未造成重大影响。局部疼痛是最常见的影响,在记录了疼痛严重程度的7例病例中,有4例疼痛剧烈。穿刺痕迹或出血是其次最常见的影响。在1例病例中,蜘蛛咬穿了患者的指甲。9例中有1例出现轻微的全身影响。有7例犬类被咬伤(粗螯蛛属和澳毒蛛属),其中2例犬主在犬被咬伤后也被咬伤。在所有7例犬类病例中,犬均死亡,咬伤后最快0.5 - 2小时死亡。这一小系列澳大利亚捕鸟蛛科蜘蛛咬伤病例表明了这些蜘蛛对人类的毒性范围。这些蜘蛛咬伤不太可能在人类中引起重大问题。该研究还表明,其毒液对犬类毒性更强。