Pampiglione S, Manson-Bahr P E, La Placa M, Borgatti M A, Micheloni F
Trans R Soc Trop Med Hyg. 1976;70(1):62-5. doi: 10.1016/0035-9203(76)90009-2.
The leishmanin skin test was used in four different areas of the Italian Adriatic coast (Emilia Romagna, Marche, San Marino and Abruzzi), old endemic areas for cutaneous leishmaniasis. The test was found to be postitive in 80% of past infections, the 20% negative reactions being found in those who had been infected 20 or more years before. In the old endemic area of Teramo there was increasing positivity with age, with a sharp rise in the over 30 years age group suggesting that there had been a sudden break in transmission 30 years ago, coinciding with the DDT campaign of 1944-45. In San Marino in the past overt infection had occurred in a number of small microfoci, centred on houses surrounded by a larger number of inapparent infection. Control studies on a number of infectious and non-infectious diseases were all negative, and there was no relationship between tuberculin and leishmanin sensitivity.
利什曼原虫皮肤试验在意大利亚得里亚海沿岸的四个不同地区（艾米利亚-罗马涅、马尔凯、圣马力诺和阿布鲁佐）进行，这些地区是皮肤利什曼病的旧流行区。该试验在80%的既往感染者中呈阳性，20%的阴性反应出现在20年或更久之前感染的人群中。在泰拉莫的旧流行区，阳性率随年龄增长而上升，30岁以上年龄组急剧上升，这表明30年前传播突然中断，与1944 - 1945年的滴滴涕防治运动相吻合。在圣马力诺，过去明显感染发生在一些小的微疫源地，以房屋为中心，周围有大量隐性感染。对多种传染病和非传染病的对照研究均为阴性，结核菌素敏感性与利什曼原虫敏感性之间没有关联。
