Kaku Tsunehisa, Ogawa Shinji, Kawano Yoshiaki, Ohishi Yoshihiro, Kobayashi Hiroaki, Hirakawa Toshio, Nakano Hitoo
School of Health Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka 812-8582, Japan.
Med Electron Microsc. 2003 Mar;36(1):9-17. doi: 10.1007/s007950300002.
The histology of ovarian tumors exhibits a wide variety of histological features. The histological classification of ovarian tumors by the World Health Organization (WHO) is based on histogenetic principles, and this classification categorizes ovarian tumors with regard to their derivation from coelomic surface epithelial cells, germ cells, and mesenchyme (the stroma and the sex cord). Epithelial ovarian tumors, which are the majority of malignant ovarian tumors, are further grouped into histological types as follows: serous, mucinous, endometrioid, clear cell, transitional cell tumors (Brenner tumors), carcinosarcoma, mixed epithelial tumor, undifferentiated carcinoma, and others. Clear cell and endometrioid carcinomas are highly associated with endometriosis. In stage distribution, serous carcinoma is found predominantly is stage III or IV. In contrast, clear cell and endometrioid carcinomas tend to remain confined to the ovary. Clear cell and endometrioid carcinomas may be unique histological types compared with serous carcinomas with respect to stage distribution and association with endometriosis.
卵巢肿瘤的组织学表现出多种多样的组织学特征。世界卫生组织（WHO）对卵巢肿瘤的组织学分类基于组织发生学原理，该分类根据卵巢肿瘤源自体腔表面上皮细胞、生殖细胞和间充质（基质和性索）对其进行分类。上皮性卵巢肿瘤是大多数恶性卵巢肿瘤，进一步分为以下组织学类型：浆液性、黏液性、子宫内膜样、透明细胞、移行细胞肿瘤（勃勒纳瘤）、癌肉瘤、混合性上皮肿瘤、未分化癌等。透明细胞癌和子宫内膜样癌与子宫内膜异位症高度相关。在分期分布上，浆液性癌主要见于Ⅲ期或Ⅳ期。相比之下，透明细胞癌和子宫内膜样癌往往局限于卵巢。就分期分布和与子宫内膜异位症的关联而言，透明细胞癌和子宫内膜样癌与浆液性癌相比可能是独特的组织学类型。
