Kwas Katarzyna, Szubert Maria, Wilczyński Jacek Radosław
Department of Surgical and Oncologic Gynaecology, 1st Department of Gynaecology and Obstetrics, Medical University of Lodz, 90-136 Łódź, Poland.
Cells. 2025 Apr 7;14(7):555. doi: 10.3390/cells14070555.
Long noncoding RNAs (lncRNAs) are RNA molecules exceeding 200 nucleotides that do not encode proteins yet play critical roles in regulating gene expression at multiple levels, such as chromatin modification and transcription. These molecules are significantly engaged in cancer progression, development, metastasis, and chemoresistance. However, the function of lncRNAs in epithelial ovarian cancer (EOC) has not yet been thoroughly studied. EOC remains challenging due to its complex molecular pathogenesis, characterized by genetic and epigenetic alterations. Emerging evidence suggests that lncRNAs, such as XIST, H19, NEAT1, and MALAT1, are involved in EOC by modulating gene expression and signaling pathways, influencing processes like cell proliferation, invasion, migration, and chemoresistance. Despite extensive research, the precise mechanism of acting of lncRNAs in EOC pathogenesis and treatment resistance still needs to be fully understood, highlighting the need for further studies. This review aims to provide an updated overview of the current understanding of lncRNAs in EOC, emphasizing their potential as biomarkers and therapeutic targets. We point out the gaps in the knowledge regarding lncRNAs' influence on epithelial ovarian cancer (EOC), deliberating on new possible research areas.
长链非编码RNA（lncRNAs）是长度超过200个核苷酸的RNA分子，它们不编码蛋白质，但在多个层面调控基因表达中发挥关键作用，如染色质修饰和转录。这些分子在癌症进展、发展、转移和化疗耐药中发挥着重要作用。然而，lncRNAs在上皮性卵巢癌（EOC）中的功能尚未得到充分研究。由于其复杂的分子发病机制，以遗传和表观遗传改变为特征，EOC的治疗仍然具有挑战性。新出现的证据表明，诸如XIST、H19、NEAT1和MALAT1等lncRNAs通过调节基因表达和信号通路参与EOC，影响细胞增殖、侵袭、迁移和化疗耐药等过程。尽管进行了广泛研究，但lncRNAs在EOC发病机制和治疗耐药中的精确作用机制仍需充分了解，这突出了进一步研究的必要性。本综述旨在提供关于EOC中lncRNAs当前认识的最新概述，强调它们作为生物标志物和治疗靶点的潜力。我们指出了关于lncRNAs对上皮性卵巢癌（EOC）影响的知识空白，探讨了新的可能研究领域。
