Diaz Eduardo M, Holsinger F Christopher, Zuniga Edgar R, Roberts Dianna B, Sorensen Douglas M
The Department of Head and Neck Surgery, The University of Texas, M. D. Anderson Cancer Center, 1515 Holcombe, Box 441, Houston, Texas 77030-4009, USA.
Head Neck. 2003 Apr;25(4):267-73. doi: 10.1002/hed.10221.
Squamous cell carcinoma (SCC) of the buccal mucosa is a rare, but especially aggressive, form of oral cavity cancer, associated with a high rate of locoregional recurrence and poor survival. We reviewed our institution's experience with 119 consecutive, previously untreated patients with buccal SCC.
We reviewed the charts of 250 patients who were seen at The University of Texas M. D. Anderson Cancer Center between January, 1974, and December, 1993. Of these, 119 were untreated and were subsequently treated exclusively at our institution. Patients who were previously treated elsewhere or whose lesions arose in other sites and only secondarily involved the buccal mucosa were excluded.
Patients with T1- or T2-sized tumors had only a 78% and 66% 5-year survival, respectively. Muscle invasion, Stensen's duct involvement, and extracapsular spread of involved lymph nodes were all associated with decreased survival (p <.05). Surgical salvage for patients with locoregional recurrence after radiation therapy was rarely successful.
SCC of the buccal mucosa is a highly aggressive form of oral cavity cancer, with a tendency to recur locoregionally. Patients with buccal mucosa SCC have a worse stage-for-stage survival rate than do patients with other oral cavity sites.
颊黏膜鳞状细胞癌（SCC）是一种罕见但侵袭性极强的口腔癌，局部区域复发率高，生存率低。我们回顾了本机构连续收治的119例未经治疗的颊黏膜SCC患者的治疗经验。
我们查阅了1974年1月至1993年12月期间在德克萨斯大学MD安德森癌症中心就诊的250例患者的病历。其中，119例未经治疗，随后仅在本机构接受治疗。排除先前在其他地方接受过治疗或病变起源于其他部位且仅继发累及颊黏膜的患者。
肿瘤大小为T1或T2的患者5年生存率分别仅为78%和66%。肌肉浸润、斯滕森导管受累以及受累淋巴结的包膜外扩散均与生存率降低相关（p <.05）。放射治疗后局部区域复发患者的手术挽救很少成功。
颊黏膜SCC是一种侵袭性很强的口腔癌，有局部区域复发的倾向。颊黏膜SCC患者的逐期生存率比其他口腔部位的患者更差。
