免疫健全和免疫缺陷小鼠体内移植的实验性肿瘤对（18）F-氟脱氧葡萄糖的摄取差异及免疫调节作用。

Differential uptake of (18)F-fluorodeoxyglucose by experimental tumors xenografted into immunocompetent and immunodeficient mice and the effect of immunomodification.

作者信息

Mamede Marcelo, Saga Tsuneo, Ishimori Takayoshi, Nakamoto Yuji, Sato Noriko, Higashi Tatsuya, Mukai Takahiro, Kobayashi Hisataka, Konishi Junji

机构信息

Department of Nuclear Medicine and Diagnostic Imaging, Graduate School of Medicine, Kyoto University, 54 Kawahara-cho, Shogoin, Sakyo-ku, Kyoto, Japan.

出版信息

Neoplasia. 2003 Mar-Apr;5(2):179-83. doi: 10.1016/s1476-5586(03)80010-6.

DOI:10.1016/s1476-5586(03)80010-6

PMID:12659691

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1502404/

Abstract

PURPOSE

To study the contribution of immunologic background to the uptake of fluorine-18-fluorodeoxyglucose ((18)F-FDG) by the tumor tissues.

METHODS

The uptakes of (18)F-FDG to the same experimental tumor model (SCCVII) xenografted into immunocompetent and immunodeficient (athymic) mice were compared. In addition, the immunomodifying effect of steroid on the uptake of (18)F-FDG by these tumors was investigated.

RESULTS

The uptake of (18)F-FDG by the tumors in immunocompetent mice was significantly higher than that in immunodeficient (athymic) mice. Although steroid pretreatment had no effect on the tumor uptake in immunodeficient mice, it significantly decreased the tumor uptake in immunocompetent mice.

CONCLUSION

The higher tumor uptake of (18)F-FDG observed in immunocompetent mice, modulated by steroid pretreatment, was contributed by the host immune reaction, probably cellular immunity employed by T-lymphocytes. These findings can clinically conclude that the intense accumulation of (18)F-FDG in the metastatic lymph nodes, which contain only a small number of cancer cells, was caused by the enhanced uptake of (18)F-FDG by activated T-lymphocytes due to host immunity against cancer cells present in metastatic lymph nodes.

摘要

目的

研究免疫背景对肿瘤组织摄取氟-18-氟脱氧葡萄糖（¹⁸F-FDG）的影响。

方法

比较¹⁸F-FDG在免疫健全和免疫缺陷（无胸腺）小鼠体内接种的同一实验性肿瘤模型（SCCVII）中的摄取情况。此外，研究了类固醇对这些肿瘤摄取¹⁸F-FDG的免疫调节作用。

结果

免疫健全小鼠体内肿瘤对¹⁸F-FDG的摄取显著高于免疫缺陷（无胸腺）小鼠。虽然类固醇预处理对免疫缺陷小鼠的肿瘤摄取没有影响，但它显著降低了免疫健全小鼠的肿瘤摄取。

结论

免疫健全小鼠中观察到的¹⁸F-FDG较高的肿瘤摄取，经类固醇预处理调节，是由宿主免疫反应导致的，可能是T淋巴细胞所采用的细胞免疫。这些发现可以在临床上推断，在仅含有少量癌细胞的转移性淋巴结中¹⁸F-FDG的强烈积聚，是由于宿主对转移性淋巴结中存在的癌细胞的免疫反应，激活的T淋巴细胞对¹⁸F-FDG摄取增加所致。