Yamada S, Kubota K, Kubota R, Ido T, Tamahashi N
Department of Nuclear Medicine and Radiology, Institute of Development, Aging and Cancer, Tohoku University, Sendai, Japan.
J Nucl Med. 1995 Jul;36(7):1301-6.
Fluorine-18-2-deoxy-2-fluoro-D-glucose ([18F]FDG) uptake and distribution in an experimentally induced inflammatory tissue were investigated.
Rats were subcutaneously inoculated with turpentine oil to induce inflammation and used for tissue distribution studies and autoradiography.
Time course study of [18F]FDG tissue distribution showed that the uptake in inflammatory tissue increased gradually until 60 min and then decreased. A longitudinal study of [18F]FDG tissue distribution showed that the uptake increased progressively to a peak 4 days after inoculation and then decreased. On the fourth day postinoculation, a section of inflammatory tissue showed characteristic changes of chronic inflammation. Macro- and micro-autoradiography showed a high density of silver grains in the abscess wall consisting of an inflammatory cell layer and granulation tissue. Grain counting on micro-autoradiography of the abscess wall showed that the highest grain density was found in the marginal zone of young fibroblasts, endothelial cells of vessels and phagocytes of neutrophils and macrophages, followed by that in the neutrophil layer and granulation tissue.
Our results indicate that [18F]FDG PET may be useful in detecting and monitoring chronic inflammatory processes.
研究了氟代脱氧葡萄糖（[18F]FDG）在实验性诱导的炎症组织中的摄取和分布情况。
给大鼠皮下注射松节油以诱导炎症，并用于组织分布研究和放射自显影。
[18F]FDG组织分布的时间进程研究表明，炎症组织中的摄取在60分钟前逐渐增加，然后下降。[18F]FDG组织分布的纵向研究表明，摄取在接种后4天逐渐增加至峰值，然后下降。接种后第4天，一部分炎症组织显示出慢性炎症的特征性变化。宏观和微观放射自显影显示，在由炎症细胞层和肉芽组织组成的脓肿壁中有高密度的银颗粒。脓肿壁微观放射自显影的颗粒计数显示，在年轻成纤维细胞、血管内皮细胞以及中性粒细胞和巨噬细胞的吞噬细胞的边缘区发现最高的颗粒密度，其次是中性粒细胞层和肉芽组织中的颗粒密度。
我们的结果表明，[18F]FDG PET可能有助于检测和监测慢性炎症过程。
