Ge Liqin, Möhwald Helmuth, Li Junbai
International Joint Lab, The Center for Molecular Science, Institute of Chemistry, Chinese Academy of Science, Beijing 100080, China.
Biochem Biophys Res Commun. 2003 Apr 4;303(2):653-9. doi: 10.1016/s0006-291x(03)00391-7.
Phospholipid vesicles on polyelectrolyte multilayer shells can be stabilized against ethanol by coating a single cationic polyelectrolyte. Confocal laser scanning microscopy (CLSM) proved that the lipids were stabilized by cationic polyelectrolytes and the permeability to small hydrophilic dyes was decreased. Measurements of fluorescence recovery after photo-bleaching (FRAP) with individual capsules enable quantification of release profiles.
通过涂覆单一阳离子聚电解质，聚电解质多层壳上的磷脂囊泡可抵抗乙醇而保持稳定。共聚焦激光扫描显微镜（CLSM）证明脂质通过阳离子聚电解质得以稳定，且对小的亲水性染料的渗透性降低。对单个胶囊进行光漂白后荧光恢复（FRAP）测量可实现释放曲线的量化。
