Max-Planck Institute of Colloids and Interfaces, Department of Interfaces, Golm/Potsdam, D14476, Germany.
Expert Opin Drug Deliv. 2013 Jan;10(1):47-58. doi: 10.1517/17425247.2013.730516. Epub 2012 Oct 18.
Red blood cells (RBCs) and lipid-based carriers on the one hand and polymeric capsules on the other hand represent two of the most widely used carriers in drug delivery. Each class of these carriers has its own set of properties, specificity and advantages. Thorough comparative studies of such systems are reported here for the first time.
In this review, RBCs are described in comparison with synthetic polymeric drug delivery vehicles using polyelectrolyte multilayer capsules as an example. Lipid-based composition of the shell in the former case is particularly attractive due to their inherent biocompatibility and flexibility of the carriers. On the other hand, synthetic approaches to fabrication of polyelectrolyte multilayer capsules permit manipulation of the permeability of their shell as well as tuning their composition, mechanical properties, release methods and targeting.
In conclusion, properties of RBCs and polyelectrolyte multilayer capsules are reported here highlighting similarities and differences in their preparation and applications. In addition, their advantages and disadvantages are discussed.
红细胞（RBC）和基于脂质的载体一方面，以及聚合胶囊另一方面，代表了药物输送中最广泛使用的两种载体。这些载体中的每一类都有其自身的一系列特性、特异性和优势。本文首次对这些系统进行了透彻的比较研究。
在本综述中，使用聚电解质多层胶囊作为示例，将 RBC 与合成聚合物药物输送载体进行了比较。由于其固有的生物相容性和载体的灵活性，前者壳的脂质组成特别有吸引力。另一方面，合成方法制备聚电解质多层胶囊允许对其壳的渗透性以及调整其组成、机械性能、释放方法和靶向进行操作。
总之，本文报道了 RBC 和聚电解质多层胶囊的性质，突出了它们在制备和应用方面的相似性和差异。此外，还讨论了它们的优缺点。
