Galzitskaya Oxana V, Garbuzynskiy Sergiy O, Ivankov Dmitry N, Finkelstein Alexei V
Institute of Protein Research, Russian Academy of Sciences, Pushchino, Moscow Region, Russia.
Proteins. 2003 May 1;51(2):162-6. doi: 10.1002/prot.10343.
We demonstrate that chain length is the main determinant of the folding rate for proteins with the three-state folding kinetics. The logarithm of their folding rate in water (k(f)) strongly anticorrelates with their chain length L (the correlation coefficient being -0.80). At the same time, the chain length has no correlation with the folding rate for two-state folding proteins (the correlation coefficient is -0.07). Another significant difference of these two groups of proteins is a strong anticorrelation between the folding rate and Baker's "relative contact order" for the two-state folders and the complete absence of such correlation for the three-state folders.
我们证明，对于具有三态折叠动力学的蛋白质，链长是折叠速率的主要决定因素。它们在水中的折叠速率（k(f)）的对数与链长L呈强烈的反相关（相关系数为-0.80）。同时，链长与两态折叠蛋白质的折叠速率无关（相关系数为-0.07）。这两组蛋白质的另一个显著差异是，两态折叠蛋白质的折叠速率与贝克的“相对接触序”之间存在强烈的反相关，而三态折叠蛋白质则完全不存在这种相关性。
