Neĭshtadt E L, Shalumovich V N, Berezkin D P
Vopr Onkol. 1976;22(1):13-6.
The study of the DNA content in nuclei of the mammary gland epithelium in 18 females with fibroadenomatosis, followed by breast cancer, and in 47 patients showing fibroadenomatosis, but no cancer subsequently, indicated that the presence of aneuploid cells in fibroadenomatous foci may be regarded as one of high risk factors of breast cancer incidence. In these patients the risk for breast cancer is 9 times as that in the remaining subjects with fibroadenomatosis.
对18例患有纤维腺瘤病并随后发展为乳腺癌的女性以及47例仅表现为纤维腺瘤病但随后未患癌症的患者的乳腺上皮细胞核DNA含量进行研究，结果表明纤维腺瘤病灶中出现非整倍体细胞可被视为乳腺癌发病的高风险因素之一。在这些患者中，患乳腺癌的风险是其余患有纤维腺瘤病患者的9倍。
