Ganina K P, Petunin Iu I, Timoshenko Ia G
Vopr Onkol. 1989;35(12):1444-9.
A method for quantitative analysis of epithelial cell nuclear polymorphism was suggested, viz. identification of general statistical population using Petunin's criterion. This criterion was employed to assess heterogeneity of visible surface of interphase epithelial cell nuclei and to assay nuclear DNA level in fibroadenomatous hyperplasia and cancer of the breast. Heterogeneity index (h), alongside with other parameters, appeared useful for quantitative assessment of the disease: heterogeneity index values ranging 0.1-0.4 point to pronounced heterogeneity of epithelial cell nucleus surface and DNA level, and are suggestive of malignant transformation of tissue, whereas benign proliferation of the epithelium is usually characterized by 0.4 less than h less than or equal to 0.9.
提出了一种上皮细胞核多态性定量分析方法，即采用彼得宁标准识别总体统计群体。该标准用于评估间期上皮细胞核可见表面的异质性，并测定乳腺纤维腺瘤样增生和癌症中的核DNA水平。异质性指数（h）与其他参数一起，对疾病的定量评估很有用：异质性指数值在0.1 - 0.4之间表明上皮细胞核表面和DNA水平存在明显异质性，提示组织发生恶性转化，而上皮细胞的良性增殖通常表现为h小于0.4且小于或等于0.9。
