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成人哮喘患病率的长期变化。

Long-term changes in adult asthma prevalence.

作者信息

Brogger J, Bakke P, Eide G E, Johansen B, Andersen A, Gulsvik A

机构信息

Dept of Thoracic Medicine, Institute of Medicine, University of Bergen, Norway.

出版信息

Eur Respir J. 2003 Mar;21(3):468-72. doi: 10.1183/09031936.03.00056103.

Abstract

There has been an increase in asthma prevalence among children. Little evidence is available regarding long-term changes in asthma prevalence in adults. Two cross-sectional studies were performed among adults aged 15-70 yrs in Oslo, Norway, in 1972 and again in 1998-1999 (n=39,998). A postal self-completed questionnaire was used. Exactly the same questions and survey methods were used in both studies. In 1998-1999, additional telephone follow-up was included for postal nonresponders. The crude prevalence of ever having had a doctor's diagnosis of asthma increased from 3.4 to 9.3%. The prevalence of wheezing increased from 17.8 to 25.8% and attacks of breathlessness from 12.6 to 16.7%. After controlling for smoking, the risk of asthma among those aged <40 yrs had tripled. The increase in asthma was 50% greater in females than males. The prevalence of symptoms increased less than asthma diagnosis. Wheezing increased by 50% in those aged <40 yrs, with smaller increases at greater ages. The increase in symptoms was seen among both asthmatics and nonasthmatics. There has been a large increase in the prevalence of asthma diagnosis and asthma-like symptoms in adults. The increase is less pronounced among those aged >40 yrs.

摘要

儿童哮喘患病率呈上升趋势。关于成人哮喘患病率的长期变化,几乎没有相关证据。1972年以及1998 - 1999年在挪威奥斯陆对15至70岁的成年人进行了两项横断面研究(n = 39,998)。采用了邮寄自填式问卷。两项研究使用了完全相同的问题和调查方法。在1998 - 1999年,对未回复邮寄问卷者增加了电话随访。曾被医生诊断为哮喘的粗患病率从3.4%升至9.3%。喘息患病率从17.8%升至25.8%,气促发作患病率从12.6%升至16.7%。在控制吸烟因素后,40岁以下人群患哮喘的风险增至三倍。女性哮喘患病率的增幅比男性高50%。症状的患病率增幅低于哮喘诊断率。40岁以下人群的喘息患病率增加了50%,年龄越大增幅越小。哮喘患者和非哮喘患者的症状均有增加。成人哮喘诊断率和哮喘样症状的患病率大幅上升。40岁以上人群的增幅不那么明显。

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