Scott A Ian
Center for Biological NMR, Chemistry Department, Texas A&M University, 3255 TAMU, College Station, Texas 77843-3255, USA.
J Org Chem. 2003 Apr 4;68(7):2529-39. doi: 10.1021/jo020728t.
The chronology of the discoveries along the pathway of vitamin B(12) biosynthesis is reviewed from a personal perspective, including discussion of the most recent finding that two pathways to B(12) exist-one aerobic and one anaerobic-which differ mainly in the ring contraction mechanisms that convert porphyrin to corrin.
本文从个人视角回顾了维生素B12生物合成途径中各项发现的时间顺序,包括对最新发现的讨论,即存在两条合成维生素B12的途径——一条需氧途径和一条厌氧途径,这两条途径的主要差异在于将卟啉转化为咕啉的环收缩机制。