维生素E结合透析器膜对血液透析患者红细胞存活的影响。

The effect of vitamin E-bonded dialyzer membrane on red blood cell survival in hemodialyzed patients.

作者信息

Nakatan Tatsuya, Takemoto Yoshiaki, Tsuchida And Kenji

机构信息

Department of Artificial Kidney, Osaka City University Medical School, Japan.

出版信息

Artif Organs. 2003 Mar;27(3):214-7. doi: 10.1046/j.1525-1594.2003.07214.x.

DOI:10.1046/j.1525-1594.2003.07214.x

PMID:12662204

Abstract

Reduced red blood cell (RBC) survival due to oxidative damage is one of the causes of anemia in patients under long-term hemodialysis. Recently, it has been shown that vitamin E-bonded dialyzer membrane is able to reduce the oxidative stress during hemodialysis. In humans, creatine content in RBC is used to measure RBC life span and erythropoietic capacity, since it rapidly declines as the RBCs become old. Therefore this study aimed to elucidate the effect of vitamin E-bonded dialyzer membrane on RBC life span by measuring creatine content in RBC.

摘要

因氧化损伤导致的红细胞（RBC）存活期缩短是长期血液透析患者贫血的原因之一。最近有研究表明，维生素E结合型透析器膜能够降低血液透析过程中的氧化应激。在人体中，红细胞中的肌酸含量可用于衡量红细胞寿命和红细胞生成能力，因为随着红细胞老化，其含量会迅速下降。因此，本研究旨在通过测量红细胞中的肌酸含量来阐明维生素E结合型透析器膜对红细胞寿命的影响。