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类Polo激酶CDC5在减数分裂I染色体分离编程中的作用。

Role of Polo-like kinase CDC5 in programming meiosis I chromosome segregation.

作者信息

Lee Brian H, Amon Angelika

机构信息

Center for Cancer Research, Howard Hughes Medical Institute, Massachusetts Institute of Technology, E17-233, 40 Ames Street, Cambridge, MA 02139, USA.

出版信息

Science. 2003 Apr 18;300(5618):482-6. doi: 10.1126/science.1081846. Epub 2003 Mar 27.

Abstract

Meiosis is a specialized cell division in which two chromosome segregation phases follow a single DNA replication phase. The budding yeast Polo-like kinase Cdc5 was found to be instrumental in establishing the meiosis I chromosome segregation program. Cdc5 was required to phosphorylate and remove meiotic cohesin from chromosomes. Furthermore, in the absence of CDC5 kinetochores were bioriented during meiosis I, and Mam1, a protein essential for coorientation, failed to associate with kinetochores. Thus, sister-kinetochore coorientation and chromosome segregation during meiosis I are coupled through their dependence on CDC5.

摘要

减数分裂是一种特殊的细胞分裂过程,其中两个染色体分离阶段紧跟在一个DNA复制阶段之后。人们发现,芽殖酵母中的Polo样激酶Cdc5在建立减数分裂I染色体分离程序中发挥了重要作用。Cdc5需要对染色体上的减数分裂黏连蛋白进行磷酸化并将其移除。此外,在缺乏CDC5的情况下,着丝粒在减数分裂I期间会双定向排列,而共定向所必需的蛋白质Mam1无法与着丝粒结合。因此,减数分裂I期间姐妹着丝粒的共定向和染色体分离通过它们对CDC5的依赖性而相互关联。

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