新生儿寻常型天疱疮：针对桥粒芯糖蛋白3的IgG4自身抗体可导致新生儿皮肤水疱。

Neonatal pemphigus vulgaris: IgG4 autoantibodies to desmoglein 3 induce skin blisters in newborns.

作者信息

Parlowsky Thomas, Welzel Julia, Amagai Masayuki, Zillikens Detlef, Wygold Thorsten

机构信息

Department of Dermatology, University of Luebeck.

出版信息

J Am Acad Dermatol. 2003 Apr;48(4):623-5. doi: 10.1067/mjd.2003.170.

DOI:10.1067/mjd.2003.170

PMID:12664033

Abstract

We report a case of neonatal pemphigus vulgaris presenting with skin lesions on the head, genital area, and right foot. Pemphigus vulgaris was diagnosed by the presence of circulating autoantibodies predominantly of the IgG4 subtype by indirect immunofluorescence microscopy and by enzyme-linked immunosorbent assay using recombinant desmoglein 3. This case demonstrates the pathogenic relevance of IgG4 autoantibodies to desmoglein 3 in the skin of neonates.

摘要

我们报告了一例新生儿寻常型天疱疮病例，其头部、生殖器区域和右脚出现皮肤病变。通过间接免疫荧光显微镜检查发现主要为IgG4亚型的循环自身抗体，并使用重组桥粒芯糖蛋白3进行酶联免疫吸附测定，从而诊断为寻常型天疱疮。该病例证明了IgG4自身抗体对新生儿皮肤中桥粒芯糖蛋白3的致病相关性。