母体抗体与发育中的血脑屏障。
Maternal antibodies and developing blood-brain barrier.
作者信息
Kowal Czeslawa, Athanassiou Andrew, Chen Huiyi, Diamond Betty
机构信息
The Center for Autoimmune and Musculoskeletal Disease, The Feinstein Institute for Medical Research, 350 Community Drive, Manhasset, NY, 11030, USA.
Hofstra North Shore-LIJ School of Medicine, 500 Hofstra University, Hempstead, NY, 11549, USA.
出版信息
Immunol Res. 2015 Dec;63(1-3):18-25. doi: 10.1007/s12026-015-8714-5.
Abstract
We briefly review the protective role of maternal antibodies during fetal development and at early postnatal stages. We describe antibody delivery to fetuses, particularly in the context of the developing blood-brain barrier (BBB), and present the essential concepts regarding the adult BBB, together with existing information on the prenatal developing BBB. We focus on maternal antibody transfer to the developing brain and the consequences of the presence of pathogenic antibodies at early stages of brain development on subsequent brain dysfunction.
摘要
我们简要回顾母体抗体在胎儿发育期间及出生后早期阶段的保护作用。我们描述抗体向胎儿的传递，特别是在发育中的血脑屏障（BBB）背景下的传递，并介绍关于成人血脑屏障的基本概念，以及有关产前发育中的血脑屏障的现有信息。我们重点关注母体抗体向发育中的大脑的转移，以及在大脑发育早期存在致病性抗体对随后脑功能障碍的影响。
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本文引用的文献
1
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Sci Transl Med. 2014 Nov 19;6(263):263ra158. doi: 10.1126/scitranslmed.3009759.
2
Embryonic intraventricular exposure to autism-specific maternal autoantibodies produces alterations in autistic-like stereotypical behaviors in offspring mice.胚胎期脑室内暴露于自闭症特异性母体自身抗体可导致子代小鼠出现类似自闭症的刻板行为改变。
Behav Brain Res. 2014 Jun 1;266:46-51. doi: 10.1016/j.bbr.2014.02.045. Epub 2014 Mar 5.
3
Recent molecular approaches to understanding astrocyte function in vivo.近年来对星形胶质细胞在体内功能的分子研究方法。
Front Cell Neurosci. 2013 Dec 24;7:272. doi: 10.3389/fncel.2013.00272.
4
Brain-reactive IgG correlates with autoimmunity in mothers of a child with an autism spectrum disorder.脑反应性 IgG 与自闭症谱系障碍儿童的母亲自身免疫相关。
Mol Psychiatry. 2013 Nov;18(11):1171-7. doi: 10.1038/mp.2013.101. Epub 2013 Aug 20.
5
Maternal antibodies from mothers of children with autism alter brain growth and social behavior development in the rhesus monkey.自闭症儿童的母亲的抗体改变恒河猴的大脑生长和社会行为发育。
Transl Psychiatry. 2013 Jul 9;3(7):e278. doi: 10.1038/tp.2013.47.
6
Maternal autism-associated IgG antibodies delay development and produce anxiety in a mouse gestational transfer model.母体自闭症相关 IgG 抗体通过小鼠妊娠期转移模型延迟发育并产生焦虑。
J Neuroimmunol. 2012 Nov 15;252(1-2):56-65. doi: 10.1016/j.jneuroim.2012.08.002. Epub 2012 Aug 27.
7
Different vascular permeability between the sensory and secretory circumventricular organs of adult mouse brain.成年鼠脑感觉和分泌室周器官之间的血管通透性不同。
Cell Tissue Res. 2012 Aug;349(2):589-603. doi: 10.1007/s00441-012-1421-9. Epub 2012 May 16.
8
Barrier mechanisms in the developing brain.发育中大脑的屏障机制。
Front Pharmacol. 2012 Mar 29;3:46. doi: 10.3389/fphar.2012.00046. eCollection 2012.
9
Perspectives on immunoglobulins in colostrum and milk.对初乳和母乳中免疫球蛋白的看法。
Nutrients. 2011 Apr;3(4):442-74. doi: 10.3390/nu3040442. Epub 2011 Apr 14.
10
IgG placental transfer in healthy and pathological pregnancies.健康与病理妊娠中的IgG胎盘转运
Clin Dev Immunol. 2012;2012:985646. doi: 10.1155/2012/985646. Epub 2011 Oct 1.
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