Kowal Czeslawa, Athanassiou Andrew, Chen Huiyi, Diamond Betty
The Center for Autoimmune and Musculoskeletal Disease, The Feinstein Institute for Medical Research, 350 Community Drive, Manhasset, NY, 11030, USA.
Hofstra North Shore-LIJ School of Medicine, 500 Hofstra University, Hempstead, NY, 11549, USA.
Immunol Res. 2015 Dec;63(1-3):18-25. doi: 10.1007/s12026-015-8714-5.
We briefly review the protective role of maternal antibodies during fetal development and at early postnatal stages. We describe antibody delivery to fetuses, particularly in the context of the developing blood-brain barrier (BBB), and present the essential concepts regarding the adult BBB, together with existing information on the prenatal developing BBB. We focus on maternal antibody transfer to the developing brain and the consequences of the presence of pathogenic antibodies at early stages of brain development on subsequent brain dysfunction.
我们简要回顾母体抗体在胎儿发育期间及出生后早期阶段的保护作用。我们描述抗体向胎儿的传递，特别是在发育中的血脑屏障（BBB）背景下的传递，并介绍关于成人血脑屏障的基本概念，以及有关产前发育中的血脑屏障的现有信息。我们重点关注母体抗体向发育中的大脑的转移，以及在大脑发育早期存在致病性抗体对随后脑功能障碍的影响。
