[Clinico-immunologic features of tick-borne encephalitis in the Tomsk region].

In 243 patients with tick-borne encephalitis 60.9% had an oblivated form, 21.3%--the meningeal, 2.5% encephalitic, 2.9%--polyencephalomyelitic and 12.4%--doublewave development of the disease. In all cases the clinical picture, blood and CSF content of asparite-aminotransferase and alanine aminotransferase was studied. The study included the level of urine diastase, blood histamine, autoantibodies and indices of destructed blood neutrophils. It was established that tick-borne encephalitis remains one of the most serious diseases of the nervous system which is accompanied by lesions of the internal organs. Changes in the studied indices are in direct correlation with the form and severity of the disease. They do not come to norm even at the moment of hospital discharge which indicates the continuation of the process.