Skurk A, Fendel K, Albrecht R
Acta Otolaryngol. 1976 Mar-Apr;81(3-4):315-22.
The gland-specific enzymes amylase, lysozyme and kallikrein the activities and their dependence on the speed of salivation were studied in normal persons. In these investigations the specification or standard ranges for differentiated secretion states is useful. In contrast to amylase activity, the activities of lysozyme and kallikrein weaken appreciably with increasing speed of salivation. The activity secreted, as measured in time units, increases. In the case of a diseased parotis, a comparison of enzyme activities with the standard values will show a significant reduction of lysozyme and amylase activity in the chronic processes. Acute inflammation affects the amylase activity slightly, but raises the lysozyme activity significantly. Parotid mixed tumours probably do not lead to any changes in the enzyme activities. The splitting up of amylase into isoenzymes by polyacrylamide gel electrophoresis and its possible importance for the diagnosis of pathological processes are discussed. First results of the splitting up of the parotid lysozyme are reported.
在正常人中研究了腮腺特异性酶淀粉酶、溶菌酶和激肽释放酶的活性及其对唾液分泌速度的依赖性。在这些研究中，区分分泌状态的规范或标准范围是有用的。与淀粉酶活性相反，溶菌酶和激肽释放酶的活性随着唾液分泌速度的增加而明显减弱。以时间单位衡量，分泌的活性增加。在腮腺疾病的情况下，将酶活性与标准值进行比较，会发现在慢性病程中溶菌酶和淀粉酶活性显著降低。急性炎症对淀粉酶活性影响轻微，但会显著提高溶菌酶活性。腮腺混合瘤可能不会导致酶活性发生任何变化。讨论了通过聚丙烯酰胺凝胶电泳将淀粉酶分离为同工酶及其对病理过程诊断的可能重要性。报告了腮腺溶菌酶分离的初步结果。
