通过X射线晶体学和1H NMR各向异性方法测定的手性间位取代二苯甲醇的对映体拆分和绝对构型
Enantioresolution and absolute configurations of chiral meta-substituted diphenylmethanols as determined by X-ray crystallographic and 1H NMR anisotropy methods.
作者信息
Kosaka Masashi, Sugito Takeo, Kasai Yusuke, Kuwahara Shunsuke, Watanabe Masataka, Harada Nobuyuki, Job Gabriel E, Shvet Alex, Pirkle William H
机构信息
Institute of Multidisciplinary Research for Advanced Materials, Tohoku University, Sendai, Japan.
出版信息
Chirality. 2003 May 5;15(4):324-8. doi: 10.1002/chir.10209.
PMID:12666239
Abstract
meta-Substituted diphenylmethanols were enantioresolved by the method of chiral phthalic acid yielding enantiopure alcohols. Their absolute configurations were unambiguously determined by X-ray crystallography of chiral phthalate esters and/or by the (1)H NMR anisotropy method using 2-methoxy-2-(1-naphthyl)propionic acid.
摘要
间位取代的二苯甲醇通过手性邻苯二甲酸方法进行对映体拆分，得到对映体纯的醇。通过手性邻苯二甲酸酯的X射线晶体学和/或使用2-甲氧基-2-(1-萘基)丙酸的(1)H NMR各向异性方法明确确定了它们的绝对构型。
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