氟化二苯甲醇的对映体拆分及其绝对构型的X射线晶体学和¹H NMR各向异性方法测定
Enantioresolution of fluorinated diphenylmethanols and determination of their absolute configurations by X-Ray crystallographic and 1H NMR anisotropy methods.
作者信息
Naito Junpei, Kosaka Masashi, Sugito Takeo, Watanabe Masataka, Harada Nobuyuki, Pirkle William H
机构信息
Institute of Multidisciplinary Research for Advanced Materials, Tohoku University, Sendai, Japan.
出版信息
Chirality. 2004 Jan;16(1):22-35. doi: 10.1002/chir.10302.
Various fluorinated diphenylmethanols were enantioresolved by the methods of chiral camphorsultam-dichlorophthalic acid (CSDP acid) and/or 2-methoxy-2-(1-naphthyl)propionic acid (MalphaNP acid) yielding enantiopure alcohols. Their absolute configurations were unambiguously determined by X-ray crystallography of CSDP esters and/or by the (1)H NMR anisotropy method of MalphaNP esters for the first time.
通过手性樟脑磺内酰胺-二氯邻苯二甲酸（CSDP酸）和/或2-甲氧基-2-（1-萘基）丙酸（MalphaNP酸）方法对多种氟化二苯甲醇进行了对映体拆分，得到了对映体纯的醇。首次通过CSDP酯的X射线晶体学和/或MalphaNP酯的（1）H NMR各向异性方法明确确定了它们的绝对构型。
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