[The relationship between human serum resistin level and body fat content, plasma glucose as well as blood pressure].

OBJECTIVE

To investigate serum resistin concentration in essential hypertension patients and the relationship between serum resistin level and body fat content, plasma glucose concentration, and blood pressure.

METHODS

Fasting serum resistin concentrations were measured with enzyme immunoassay in 71 cases (including 33 men and 38 women), and oral glucose tolerance test and insulin release test were performed in all cases for calculating glucose area under the curve (AUC(G)), the ratio of change in insulin to change in glucose during the first 30 min after glucose ingestion (Delta I(30)/Delta G(30)) and insulin sensitivity index (ISI) according to Cederholm's formula. Systolic pressure (SBP), diastolic pressure (DBP), height, body weight, waist circumference and hip circumference were measured to calculate body mass index (BMI), body fat percentage (BF%) and waist-hip ratio (WHR).

RESULTS

Pearson analysis showed that fasting serum resistin concentrations were correlated with AUC(G) (r = 0.380, P < 0.001), BF% (r = 0.353, P < 0.01), ISI (r = -0.242, P < 0.05) and Delta I(30)/Delta G(30) (r = -0.298, P < 0.05), but not correlated with SBP, DBP, BMI and WHR. After adjustment for age and BMI, partial correlation analysis showed that fasting serum resistin concentrations were correlated with AUC(G) (r = 0.268, P < 0.05), Delta I(30)/Delta G(30) (r = -0.247, P < 0.05) and not correlated with ISI. A stepwise multiple linear regression analysis showed that resisitin was a significant independent predictor of AUC(G).

CONCLUSION

The strong correlation between fasting serum resistin levels and AUC(G), and BF% suggests a possibility that resistin link obesity to diabetes in humans.