Zhang Jianliang, Qin Yongwen, Zheng Xing, Qiu Jianli, Gong Li, Mao Hongjuan, Jia Weiping, Guo Jizhen
Department of Cardiology, Changhai Hospital, Second Military Medical University, Shanghai 200433, China.
Zhonghua Yi Xue Za Zhi. 2002 Dec 10;82(23):1609-12.
To investigate serum resistin concentration in essential hypertension patients and the relationship between serum resistin level and body fat content, plasma glucose concentration, and blood pressure.
Fasting serum resistin concentrations were measured with enzyme immunoassay in 71 cases (including 33 men and 38 women), and oral glucose tolerance test and insulin release test were performed in all cases for calculating glucose area under the curve (AUC(G)), the ratio of change in insulin to change in glucose during the first 30 min after glucose ingestion (Delta I(30)/Delta G(30)) and insulin sensitivity index (ISI) according to Cederholm's formula. Systolic pressure (SBP), diastolic pressure (DBP), height, body weight, waist circumference and hip circumference were measured to calculate body mass index (BMI), body fat percentage (BF%) and waist-hip ratio (WHR).
Pearson analysis showed that fasting serum resistin concentrations were correlated with AUC(G) (r = 0.380, P < 0.001), BF% (r = 0.353, P < 0.01), ISI (r = -0.242, P < 0.05) and Delta I(30)/Delta G(30) (r = -0.298, P < 0.05), but not correlated with SBP, DBP, BMI and WHR. After adjustment for age and BMI, partial correlation analysis showed that fasting serum resistin concentrations were correlated with AUC(G) (r = 0.268, P < 0.05), Delta I(30)/Delta G(30) (r = -0.247, P < 0.05) and not correlated with ISI. A stepwise multiple linear regression analysis showed that resisitin was a significant independent predictor of AUC(G).
The strong correlation between fasting serum resistin levels and AUC(G), and BF% suggests a possibility that resistin link obesity to diabetes in humans.
探讨原发性高血压患者血清抵抗素浓度及其与体脂含量、血糖浓度和血压之间的关系。
采用酶免疫分析法测定71例患者（其中男性33例，女性38例）空腹血清抵抗素浓度，所有患者均进行口服葡萄糖耐量试验和胰岛素释放试验，以计算葡萄糖曲线下面积（AUC(G)）、葡萄糖摄入后最初30分钟内胰岛素变化与葡萄糖变化的比值（Delta I(30)/Delta G(30)）以及根据Cederholm公式计算的胰岛素敏感性指数（ISI）。测量收缩压（SBP）、舒张压（DBP）、身高、体重、腰围和臀围，以计算体重指数（BMI）、体脂百分比（BF%）和腰臀比（WHR）。
Pearson分析显示，空腹血清抵抗素浓度与AUC(G)（r = 0.380，P < 0.001）、BF%（r = 0.353，P < 0.01）、ISI（r = -0.242，P < 0.05）和Delta I(30)/Delta G(30)（r = -0.298，P < 0.05）相关，但与SBP、DBP、BMI和WHR无关。在调整年龄和BMI后，偏相关分析显示空腹血清抵抗素浓度与AUC(G)（r = 0.268，P < 0.05）、Delta I(30)/Delta G(30)（r = -0.247，P < 0.05）相关，与ISI无关。逐步多元线性回归分析显示，抵抗素是AUC(G)的显著独立预测因子。
空腹血清抵抗素水平与AUC(G)和BF%之间的强相关性提示抵抗素可能将人类肥胖与糖尿病联系起来。
