Department of Sports Medicine, The First Hospital of Jilin University, Changchun, Jilin 130021, China.
Department of Orthopaedic Surgery, The First Hospital of Jilin University, Changchun, Jilin 130021, China.
Mediators Inflamm. 2019 Jan 28;2019:1532164. doi: 10.1155/2019/1532164. eCollection 2019.
Resistin may be involved in the pathogenesis of osteoarthritis (OA), but a systematic understanding of the role of resistin in OA is lacking.
We reviewed studies that evaluated the role of resistin in OA. The expression levels of resistin in vitro experiments and OA/rheumatoid arthritis (RA) patients were analyzed. We also studied potential resistin receptors and the signaling pathways that these receptors activate, ultimately leading to cartilage degeneration.
Resistin levels in both the serum and synovial fluid were higher in OA and RA patients than in healthy subjects. Overall, resistin levels are much higher in serum than in synovial fluid. In human cartilage, resistin induces the expression of proinflammatory factors such as degradative enzymes, leading to the inhibition of cartilage matrix synthesis, perhaps by binding to Toll-like receptor 4 and the adenylyl cyclase-associated protein 1 receptor, which then activates the p38-mitogen-activated phosphate kinase, protein kinase A-cyclic AMP, nuclear factor-B, and C/enhancer-binding protein signaling pathways.
Resistin levels are higher in OA patients than in healthy controls; however, the precise role of resistin in the pathogenesis of OA needs to be studied further. Resistin may be a novel therapeutic target in OA in the future.
抵抗素可能参与骨关节炎（OA）的发病机制，但对抵抗素在 OA 中的作用缺乏系统的认识。
我们回顾了评估抵抗素在 OA 中作用的研究。分析了体外实验和 OA/类风湿关节炎（RA）患者中抵抗素的表达水平。我们还研究了潜在的抵抗素受体及其激活的信号通路，这些受体最终导致软骨退化。
OA 和 RA 患者的血清和滑液中抵抗素水平均高于健康受试者。总体而言，血清中的抵抗素水平远高于滑液。在人软骨中，抵抗素诱导促炎因子如降解酶的表达，从而抑制软骨基质合成，这可能是通过与 Toll 样受体 4 和腺苷酸环化酶相关蛋白 1 受体结合，然后激活 p38-有丝分裂原激活的磷酸激酶、蛋白激酶 A-cAMP、核因子-B 和 C/增强子结合蛋白信号通路来实现的。
OA 患者的抵抗素水平高于健康对照组；然而，抵抗素在 OA 发病机制中的确切作用仍需进一步研究。抵抗素将来可能成为 OA 的一种新的治疗靶点。
