Samsamshariat Seyed Ziyae Aldin, Sakhaei Fariba, Salehizadeh Leila, Keshvari Mahtab, Asgary Sedigheh
Department of Clinical Biochemistry, Isfahan Pharmaceutical Sciences Research Center, School of Pharmacy and Pharmaceutical Sciences, Isfahan University of Medical Sciences, Isfahan, Iran.
Heart Failure Research Center, Cardiovascular Research Institute, Isfahan University of Medical Science, Isfahan, Iran.
Adv Biomed Res. 2019 Feb 27;8:16. doi: 10.4103/abr.abr_126_18. eCollection 2019.
Resistin is peptides that signal the functional status of adipose tissue to the brain and other target organs. It causes insulin resistance and affects the vascular endothelial dysfunction. However, the function and relation between resistin in endothelin-1 (ET-1), which leads to the endothelial dysfunction in humans are enigmatic.
In a cross-sectional study of 76 participants (38 metabolic syndrome patients and 38 healthy participants), biochemical and clinical parameters, including lipid profile, fasting glucose, resistin, ET-1, C-reactive protein (CRP), flow-mediated dilation (FMD), and hypertension were determined and compared between the two groups.
Multiple linear regression analysis was performed with age- and sex-adjusted plasma resistin levels, FMD, and ET-1 as the dependent variables. Analysis showed that weight, body mass index, triglycerides (TGs), and ET-1 were statistically significant correlated with serum resistin. FMD has negative significantly correlated with weight ( = -0.491, = 0.001), waist circumference ( = -0.491, = 0.001), waist-to-hip ratio ( = -0.0444, = 0.001), and ET-1 ( = -0.075, = 0.050), but it has significantly correlated with systolic blood pressure (SBP) ( = 0.290, = 0.016), diastolic blood pressure (DBP) ( = 0.275, = 0.023), and high-density lipoprotein cholesterol (HDL-C) ( = -0.266, = 0.050), and ET-1, but it has significantly correlated with SBP, DBP, and HDL-C. ET-1 is significantly correlated with TGs ( = -0.436, = 0.006), total cholesterol ( = 0.452, = 0.004), low-density lipoprotein cholesterol ( = 0.454, = 0.004), and resistin ( = 0.282, = 0.050), whereas it has negative significantly correlated with HDL-C ( = 0.346, = 0.034), FMD ( = -0.075, = 0.050.
In this study, results shown plasma ET-1 and resistin are suggested as risk factors for the development of endothelial dysfunction and with further study, it is possible that can diagnose the risk of diabetes and cardiovascular disease in the early stages.
抵抗素是一种向大脑和其他靶器官传递脂肪组织功能状态的肽。它会导致胰岛素抵抗，并影响血管内皮功能障碍。然而，抵抗素在导致人类内皮功能障碍的内皮素-1（ET-1）中的作用及关系尚不明确。
在一项对76名参与者（38名代谢综合征患者和38名健康参与者）的横断面研究中，测定并比较了两组的生化和临床参数，包括血脂谱、空腹血糖、抵抗素、ET-1、C反应蛋白（CRP）、血流介导的血管舒张功能（FMD）和高血压情况。
以年龄和性别校正后的血浆抵抗素水平、FMD和ET-1作为因变量进行多元线性回归分析。分析表明，体重、体重指数、甘油三酯（TGs）和ET-1与血清抵抗素在统计学上显著相关。FMD与体重（r = -0.491，P = 0.001）、腰围（r = -0.491，P = 0.001）、腰臀比（r = -0.0444，P = 0.001）和ET-1（r = -0.075，P = 0.050）呈显著负相关，但与收缩压（SBP）（r = 0.290，P = 0.016）、舒张压（DBP）（r = 0.275，P = 0.023）和高密度脂蛋白胆固醇（HDL-C）（r = -0.266，P = 0.050）呈显著相关，且与ET-1、SBP、DBP和HDL-C也呈显著相关。ET-1与TGs（r = -0.436，P = 0.006）、总胆固醇（r = 0.452，P = 0.004）、低密度脂蛋白胆固醇（r = 0.454，P = 0.004）和抵抗素（r = 0.282，P = 0.050）显著相关，而与HDL-C（r = 0.346，P = 0.034）、FMD（r = -0.075，P = 0.050）呈显著负相关。
在本研究中，结果表明血浆ET-1和抵抗素被认为是内皮功能障碍发生的危险因素，并且通过进一步研究，有可能在早期诊断糖尿病和心血管疾病的风险。
