• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

福莫司汀类似物对人黑色素瘤细胞系的合成及生物学评价

Synthesis and biological evaluation of Fotemustine analogues on human melanoma cell lines.

作者信息

Winum Jean Yves, Bouissière Jean Luc, Passagne Isabelle, Evrard Alexandre, Montero Véronique, Cuq Pierre, Montero Jean Louis

机构信息

Laboratoire de chimie biomoléculaire, UMR 5032, Université Montpellier II-CNRS-laboratoires Mayoly Spindler, ENSCM, 8, rue de l'Ecole Normale, 34296 cedex, Montpellier, France.

出版信息

Eur J Med Chem. 2003 Mar;38(3):319-24. doi: 10.1016/s0223-5234(03)00014-x.

DOI:10.1016/s0223-5234(03)00014-x
PMID:12667699
Abstract

Two new analogues of Fotemustine have been synthesized and tested on two melanoma cell lines. Compounds 4 and 8 proved to be more potent than the reference compound on A375 cell line which express the MGMT enzyme involved in the chemoresistance of tumoral cells.

摘要

已合成了福莫司汀的两种新类似物，并在两种黑色素瘤细胞系上进行了测试。化合物4和8在表达参与肿瘤细胞化疗耐药性的MGMT酶的A375细胞系上被证明比参考化合物更有效。

相似文献

1
Synthesis and biological evaluation of Fotemustine analogues on human melanoma cell lines.福莫司汀类似物对人黑色素瘤细胞系的合成及生物学评价
Eur J Med Chem. 2003 Mar;38(3):319-24. doi: 10.1016/s0223-5234(03)00014-x.
2
Cytotoxicity, DNA damage, and apoptosis induced by new fotemustine analogs on human melanoma cells in relation to O6-methylguanine DNA-methyltransferase expression.新型福莫司汀类似物对人黑色素瘤细胞诱导的细胞毒性、DNA损伤及凋亡与O6-甲基鸟嘌呤DNA甲基转移酶表达的关系
J Pharmacol Exp Ther. 2003 Nov;307(2):816-23. doi: 10.1124/jpet.103.051938. Epub 2003 Sep 11.
3
Acquired resistance of melanoma cells to the antineoplastic agent fotemustine is caused by reactivation of the DNA repair gene MGMT.黑色素瘤细胞对抗肿瘤药物福莫司汀产生获得性耐药是由DNA修复基因MGMT的重新激活引起的。
Int J Cancer. 2001 Apr 1;92(1):123-9.
4
Activity of fotemustine in medulloblastoma and malignant glioma xenografts in relation to O6-alkylguanine-DNA alkyltransferase and alkylpurine-DNA N-glycosylase activity.福莫司汀在髓母细胞瘤和恶性胶质瘤异种移植瘤中的活性与O6-烷基鸟嘌呤-DNA烷基转移酶及烷基嘌呤-DNA N-糖基化酶活性的关系
Clin Cancer Res. 1998 Feb;4(2):463-8.
5
Enhancement of fotemustine (Muphoran) cytotoxicity by amifostine in malignant melanoma cell lines.氨磷汀增强福莫司汀（Muphoran）对恶性黑色素瘤细胞系的细胞毒性作用。
Anticancer Drugs. 2002 Feb;13(2):141-7. doi: 10.1097/00001813-200202000-00005.
6
Alterations of DNA repair in melanoma cell lines resistant to cisplatin, fotemustine, or etoposide.对顺铂、福莫司汀或依托泊苷耐药的黑色素瘤细胞系中DNA修复的改变。
J Invest Dermatol. 2000 Jan;114(1):34-9. doi: 10.1046/j.1523-1747.2000.00844.x.
7
In vitro chemosensitivity testing of Fotemustine (S 10036), a new antitumor nitrosourea.
Cancer Chemother Pharmacol. 1990;25(5):337-41. doi: 10.1007/BF00686233.
8
In vitro evaluation of fotemustine as a potential agent for limb perfusion in melanoma.福莫司汀作为黑色素瘤肢体灌注潜在药物的体外评估。
Melanoma Res. 1998 Feb;8(1):67-75. doi: 10.1097/00008390-199802000-00012.
9
Inhibition of O6-methylguanine-DNA methyltransferase by glucose-conjugated inhibitors: comparison with nonconjugated inhibitors and effect on fotemustine and temozolomide-induced cell death.葡萄糖共轭抑制剂对O6-甲基鸟嘌呤-DNA甲基转移酶的抑制作用：与非共轭抑制剂的比较及对福莫司汀和替莫唑胺诱导细胞死亡的影响
J Pharmacol Exp Ther. 2004 Nov;311(2):585-93. doi: 10.1124/jpet.104.071316. Epub 2004 Jul 13.
10
O(6)-methylguanine DNA-methyltransferase (MGMT) overexpression in melanoma cells induces resistance to nitrosoureas and temozolomide but sensitizes to mitomycin C.黑色素瘤细胞中O(6)-甲基鸟嘌呤DNA甲基转移酶（MGMT）的过表达可诱导对亚硝基脲和替莫唑胺的耐药性，但对丝裂霉素C敏感。
Toxicol Appl Pharmacol. 2006 Mar 1;211(2):97-105. doi: 10.1016/j.taap.2005.06.009. Epub 2005 Jul 22.

引用本文的文献

1
An attempt to prepare sulfonyl analogues of fotemustine: unexpected rearrangement to sulfamate during nitrosation step.制备福莫司汀磺酰类似物的尝试：亚硝化步骤中意外重排为氨基磺酸酯。
RSC Adv. 2023 Dec 11;13(50):35741-35754. doi: 10.1039/d3ra07001h. eCollection 2023 Nov 30.
2
Asymmetric Transfer Hydrogenation as a Key Step in the Synthesis of the Phosphonic Acid Analogs of Aminocarboxylic Acids.不对称转移氢化作为合成氨基羧酸膦酸类似物的关键步骤。
Chemistry. 2023 Dec 22;29(72):e202302171. doi: 10.1002/chem.202302171. Epub 2023 Sep 20.
3
New bi-phosphonate derivative: Synthesis, characterization, antioxidant activity in vitro and via cyclic voltammetry mode and evaluation of its inhibition of SARS-CoV-2 main protease.
新型双膦酸盐衍生物：合成、表征、体外抗氧化活性及循环伏安法测定以及对其抑制新型冠状病毒2型主要蛋白酶的评估
J Mol Struct. 2023 Jul 15;1284:135356. doi: 10.1016/j.molstruc.2023.135356. Epub 2023 Mar 15.
4
Synthesis, Spectroscopic Characterization, and Antibacterial Evaluation of Novel Functionalized Sulfamidocarbonyloxyphosphonates.新型功能化磺酰胺羰氧基膦酸酯的合成、光谱表征和抗菌评价。
Molecules. 2018 Jul 10;23(7):1682. doi: 10.3390/molecules23071682.
5
Influence of the Expression Level of O6-Alkylguanine-DNA Alkyltransferase on the Formation of DNA Interstrand Crosslinks Induced by Chloroethylnitrosoureas in Cells: A Quantitation Using High-Performance Liquid Chromatography-Mass Spectrometry.O6-烷基鸟嘌呤-DNA烷基转移酶表达水平对氯乙基亚硝脲诱导细胞内DNA链间交联形成的影响：采用高效液相色谱-质谱联用的定量分析
PLoS One. 2015 Mar 23;10(3):e0121225. doi: 10.1371/journal.pone.0121225. eCollection 2015.
6
tert-Butyl N-[N,N-bis-(2-chloro-ethyl)sulfamo-yl]-N-(2-chloro-ethyl)carbamate.N-[N,N-双-(2-氯乙基)氨磺酰基]-N-(2-氯乙基)氨基甲酸叔丁酯
Acta Crystallogr Sect E Struct Rep Online. 2009 Sep 26;65(Pt 10):o2543-4. doi: 10.1107/S1600536809038185.