Schluns Kimberly S, Lefrançois Leo
Division of Immunology, University of Connecticut Health Center, 263 Farmington Avenue, Farmington, Connecticut 06030-1319, USA.
Nat Rev Immunol. 2003 Apr;3(4):269-79. doi: 10.1038/nri1052.
Evidence has accumulated that cytokines have a fundamental role in the differentiation of memory T cells. Here, we follow the CD8+ T cell from initial activation to memory-cell generation, indicating the checkpoints at which cytokines determine the fate of the T cell. Members of the common cytokine-receptor gamma-chain (gammac)-cytokine family--in particular, interleukin-7 (IL-7) and IL-15--act at each stage of the immune response to promote proliferation and survival. In this manner, a stable and protective, long-lived memory CD8+ T-cell pool can be propagated and maintained.
越来越多的证据表明，细胞因子在记忆性T细胞的分化过程中起着至关重要的作用。在此，我们追踪CD8+ T细胞从初始激活到记忆细胞生成的过程，指出细胞因子决定T细胞命运的各个检查点。常见细胞因子受体γ链（γc）-细胞因子家族的成员——特别是白细胞介素-7（IL-7）和IL-15——在免疫反应的每个阶段发挥作用，以促进增殖和存活。通过这种方式，可以增殖并维持一个稳定、具有保护性的长寿记忆性CD8+ T细胞库。
