自然杀伤基因复合体编码的免疫功能。

Immune functions encoded by the natural killer gene complex.

作者信息

Yokoyama Wayne M, Plougastel Beatrice F M

机构信息

Howard Hughes Medical Institute, Rheumatology Division, Department of Medicine, Barnes-Jewish Hospital and Washington University School of Medicine, Box 8045, 660 South Euclid Avenue, St Louis, Missouri 63110, USA.

出版信息

Nat Rev Immunol. 2003 Apr;3(4):304-16. doi: 10.1038/nri1055.

DOI:10.1038/nri1055

PMID:12669021

Abstract

There has been marked progress in our understanding of the role of natural killer (NK) cells in immune responses, mainly due to the identification of NK-cell receptors and their ligands. The genes encoding many NK-cell receptors are located in the NK-gene complex (NKC). Here, we review the properties of NKC-encoded receptors, and provide a genomic and conceptual framework for an insight into NK-cell function and biology.

摘要

我们对自然杀伤（NK）细胞在免疫反应中作用的理解取得了显著进展，这主要归功于NK细胞受体及其配体的鉴定。许多NK细胞受体的编码基因位于NK基因复合体（NKC）中。在此，我们综述了NKC编码受体的特性，并提供了一个基因组和概念框架，以深入了解NK细胞的功能和生物学特性。