Niedner R
Klinik für Dermatologie, Klinikum Ernst von Bergmann gGmbH, Potsdam.
Hautarzt. 2003 Apr;54(4):338-41. doi: 10.1007/s00105-003-0488-3. Epub 2003 Feb 28.
Topical corticosteroids (TCC) have significantly shaped dermatological therapy for five decades. A few months ago the TCC were joined by competition, the topical inhibitors of calcineurin (TIC), wrongly termed topical immunomodulators. The present paper reviews the pharmacological effects and clinical efficacy of TIC, compares the risks, benefits and costs of those two groups of topical drugs and develops a position on the use of TIC. While TIC have ushered in a new era of topical anti-inflammatory therapy, the age of TCC is far from over.
外用皮质类固醇（TCC）在过去五十年中显著地塑造了皮肤病治疗的格局。几个月前，TCC迎来了竞争，即钙调神经磷酸酶外用抑制剂（TIC），但它被错误地称为外用免疫调节剂。本文回顾了TIC的药理作用和临床疗效，比较了这两类外用药物的风险、益处和成本，并就TIC的使用表明了立场。虽然TIC开启了外用抗炎治疗的新时代，但TCC的时代远未结束。
