D'Elia A V, Pellizzari L, Puppin C, Driul L, Marchesoni D, Damante G
Dipartimento di Scienze e Tecnologie Biomediche, Università di Udine, Italy.
Horm Metab Res. 2003 Jan;35(1):24-8. doi: 10.1055/s-2003-38387.
Relaxin is a peptide hormone that, in humans, is encoded by two genes referred to as H1 and H2, both located into chromosome 9p24.1. We have searched for polymorphisms in the 5'-flanking sequence of these genes. Both genes possess a CT repeat followed by a GT repeat. CT and GT repeats of the H2 gene are longer than those of the H1 gene. Moreover, CT and GT repeats of the H2 gene, but not those of the H1 gene, show length polymorphism. Protein-DNA interaction experiments suggest that difference between the H1 and H2 GT repeats may have arisen because the requirements of the transcriptional regulation of the two genes are different.
松弛素是一种肽类激素，在人类中，由两个称为H1和H2的基因编码，这两个基因都位于9号染色体的p24.1区域。我们在这些基因的5'侧翼序列中寻找多态性。两个基因都有一个CT重复序列，后面跟着一个GT重复序列。H2基因的CT和GT重复序列比H1基因的长。此外，H2基因的CT和GT重复序列存在长度多态性，而H1基因的则没有。蛋白质-DNA相互作用实验表明，H1和H2基因GT重复序列之间的差异可能是由于两个基因转录调控的需求不同而产生的。
