Jacobs Michael, Young Paul
Centre for Hepatology, Department of Medicine, Royal Free & University College Medical School, Rowland Hill Street, London, NW3 2PF, UK.
Curr Opin Investig Drugs. 2003 Feb;4(2):168-71.
Dengue is an emerging viral pathogen of growing global importance, infecting up to 100 million people annually. Although there have been many efforts over the last six decades to produce a vaccine to combat this infection, few have been able to meet the challenges posed by the unusual interplay between this virus and its human host. However, recent progress in molecular-based vaccine strategies, as well as a renewed commitment by the World Health Organisation to co-ordinate global efforts on vaccine development, finally provides hope that control of this serious disease may be at hand.
登革热是一种新出现的病毒病原体，在全球范围内的重要性日益增加，每年感染多达1亿人。尽管在过去六十年里人们为研发一种对抗这种感染的疫苗付出了诸多努力，但很少有疫苗能够应对这种病毒与其人类宿主之间异常相互作用所带来的挑战。然而，基于分子的疫苗策略最近取得的进展，以及世界卫生组织重新承诺协调全球疫苗研发工作，最终带来了希望，即或许即将能够控制这种严重疾病。
