[血管内皮生长因子和血管内皮生长因子-C在喉癌中的表达及其临床意义]
[Expression of VEGF and VEGF-C in laryngeal carcinoma and their clinical significance].
作者信息
Yang Yan, Ge Rongming
机构信息
Department of Otolaryngology, Shanghai Punan Hospital, Shanghai, 200125.
出版信息
Lin Chuang Er Bi Yan Hou Ke Za Zhi. 2002 Dec;16(12):650-2.
OBJECTIVE
To study the gene expression of Vascular Endothelial Growth Factor (VEGF) and Vascular Endothelial Growth Factor C (VEGF-C) in laryngeal carcinoma and their relation with clinic pathologic features.
METHOD
VEGF and VEGF C gene expression in 20 cases of fresh laryngeal carcinoma, cutting edge and normal tissue were examined by reverse transcription polymerase chain reaction (RT-PCR).
RESULT
The gene expression of VEGF and VEGF-C is different among laryngeal carcinoma, cutting edge and normal tissue in the same patient. In laryngeal carcinoma, the gene expression of VEGF, VEGF-C were not associated with age, sex, site, T stage and histological grade of differentiation. Expression of VEGF, VEGF-C in laryngeal carcinoma was significantly higher in lymph node positive group than in lymph node negative group.
CONCLUSION
VEGF, VEGF-C have prognostic significance in laryngeal carcinoma.
目的
研究血管内皮生长因子（VEGF）和血管内皮生长因子C（VEGF-C）在喉癌中的基因表达及其与临床病理特征的关系。
方法
采用逆转录聚合酶链反应（RT-PCR）检测20例新鲜喉癌组织、手术切缘组织及正常组织中VEGF和VEGF-C基因的表达。
结果
同一患者的喉癌组织、手术切缘组织及正常组织中VEGF和VEGF-C基因表达存在差异。在喉癌中，VEGF、VEGF-C基因表达与年龄、性别、部位、T分期及组织学分化程度无关。喉癌组织中VEGF、VEGF-C在淋巴结阳性组的表达明显高于淋巴结阴性组。
结论
VEGF、VEGF-C在喉癌中具有预后意义。
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