Frank D W, Gray J E, Weaver R N
Am J Pathol. 1976 May;83(2):367-82.
The renal toxicity of the Schardinger dextrins, alpha and beta-cyclodextrin, is manifested as a series of alterations in the vacuolar organelles of the proximal convoluted tubule. These changes begin as an increase of apical vacuoles and the appearance of giant lysosomes. The giant lysosomes characteristic of cyclodextrin nephrosis are notable because of the prominent acicular microcrystals embedded in the lysosomal matrix. Giant vacuoles devoid of acid phosphatase reaction product are found in advanced lesions. The vacuolar apparatus shows advanced changes prior to manifestation of lesions in mitochondria and other organelles. These observations indicate a role of the vacuologenic apparatus in the nephrotic process. Intracellular concentration of toxin via the lysosomal pathway represents a perversion of the physiologic function of the proximal tubule which ultimately leads to cell death.
沙尔丁格糊精、α-环糊精和β-环糊精的肾毒性表现为近端曲管空泡细胞器的一系列改变。这些变化始于顶端空泡增多和巨型溶酶体的出现。环糊精肾病特有的巨型溶酶体很显著，因为溶酶体基质中嵌有突出的针状微晶。在晚期病变中发现缺乏酸性磷酸酶反应产物的巨大空泡。在空泡器显示出晚期变化之后，线粒体和其他细胞器才出现病变。这些观察结果表明空泡形成器在肾病过程中起作用。通过溶酶体途径使毒素在细胞内浓缩，这代表近端小管生理功能的反常，最终导致细胞死亡。
