一种分子弹头及其靶点：组织转谷氨酰胺酶与乳糜泻

A molecular warhead and its target: tissue transglutaminase and Celiac Sprue.

作者信息

Schuppan Detlef, Dieterich Walburga

机构信息

First Department of Medicine, University of Erlangen-Nuernberg, Ulmenweg 18, 91054 Erlangen, Germany.

出版信息

Chem Biol. 2003 Mar;10(3):199-201. doi: 10.1016/s1074-5521(03)00055-3.

DOI:10.1016/s1074-5521(03)00055-3

PMID:12670530

Abstract

The substitution of a glutamine residue with 6-diazo-5-oxo-norleucine (DON) transforms an immunodominant gluten peptide into a potent inhibitor of tissue transglutaminase. DON-modified peptides could be useful for the study and therapy of celiac sprue.

摘要

用6-重氮-5-氧代正亮氨酸（DON）取代谷氨酰胺残基可将一种免疫显性的麸质肽转化为组织转谷氨酰胺酶的有效抑制剂。DON修饰的肽可能有助于乳糜泻的研究和治疗。